TABLE OF CONTENTS
1 INTRODUCTION 84
1.1 OBJECTIVES OF THE STUDY 84
1.2 MARKET DEFINITION 84
1.3 OVERVIEW OF THE MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET 84
1.4 LIMITATIONS 87
1.5 MARKETS COVERED 87
2 MARKET SEGMENTATION 92
2.1 MARKETS COVERED 92
2.2 GEOGRAPHICAL SCOPE 93
2.3 YEARS CONSIDERED FOR THE STUDY 94
2.4 CURRENCY AND PRICING 94
2.5 DBMR TRIPOD DATA VALIDATION MODEL 95
2.6 MULTIVARIATE MODELLING 98
2.7 TREATMENT LIFELINE CURVE 98
2.8 PRIMARY INTERVIEWS WITH KEY OPINION LEADERS 99
2.9 DBMR MARKET POSITION GRID 100
2.10 MARKET APPLICATION COVERAGE GRID 101
2.11 VENDOR SHARE ANALYSIS 102
2.12 SECONDARY SOURCES 103
2.13 ASSUMPTIONS 103
3 EXECUTIVE SUMMARY 104
4 PREMIUM INSIGHTS 107
4.1 KEY TRENDS 108
4.2 COST OF TREATMENT 109
4.3 KEY PLAYERS STRATEGIES 110
4.4 LONG TERM GROWTH APPROACH 111
5 EPIDEMIOLOGY 112
6 INDUSTRY INSIGHTS 116
6.1 PATENT ANALYSIS 116
6.2 DEMOGRAPHIC TRENDS 118
6.3 PATIENT FLOW DIAGRAM 119
6.4 KEY PRICING STRATEGIES 120
6.5 KEY PATIENT ENROLLMENT STRATEGIES 120
7 MARKET OVERVIEW 123
7.1 DRIVERS 125
7.1.1 INCREASING PREVALENCE AND INCIDENCE OF SJS/TEN 125
7.1.2 ADVANCES IN DRUG DEVELOPMENT FOR SJS/TEN TREATMENT 126
7.1.3 INCREASING AWARENESS ABOUT THE RARE DISEASE SJS/TEN 126
7.1.4 GOVERNMENT INITIATIVES FOR SJS/TEN TREATMENT 127
7.2 RESTRAINTS 129
7.2.1 HIGH COST ASSOCIATED WITH THE TREATMENT OF SJS/TEN 129
7.2.2 LIMITED AVAILABILITY OF SPECIALIZED CARE FOR SJS/TEN TREATMENT 129
7.3 OPPORTUNITIES 130
7.3.1 DEVELOPING EFFECTIVE AND SAFE TREATMENT FOR SJS/TEN 130
7.3.2 INCREASING RESEARCH AND DEVELOPMENT ACTIVITIES FOR SJS/TEN TREATMENT 131
7.4 CHALLENGES 131
7.4.1 STRINGENT GOVERNMENT REGULATIONS FOR APPROVAL OF TREATMENT FOR SJS/TEN 131
7.4.2 LONG TERM COMPLICATIONS AND ADVERSE EFFECTS OF MEDICATIONS USED IN THE SJS/TEN TREATMENT 132
8 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY TREATMENT 133
8.1 OVERVIEW 134
8.2 MEDICATIONS 137
8.2.1 ANTIHISTAMINES 138
8.2.1.1 HYDROXYZINE 138
8.2.1.2 FEXOFENADINE 138
8.2.2 CORTICOSTEROID 139
8.2.2.1 DEXAMETHASONE 139
8.2.2.2 PREDNISOLONE 139
8.2.2.3 METHYLPREDNISOLONE 139
8.2.2.4 HYDROCORTISONE 139
8.2.2.5 OTHERS 139
8.2.3 ANTIBIOTICS 139
8.2.3.1 NAFCILLIN 140
8.2.3.2 GENTAMICIN 140
8.2.3.3 OTHERS 140
8.2.4 ANALGESICS 140
8.2.4.1 MORPHINE 140
8.2.4.2 FENTANYL CITRATE 141
8.2.4.3 OTHERS 141
8.2.5 ANTICOAGULANTS 141
8.2.6 ANTISEPTICS 141
8.2.6.1 CHLORHEXIDINE GLUCONATE 141
8.2.6.1.1 PERIOGARD 142
8.2.6.1.2 PERIDEX 142
8.2.6.1.3 AVAGARD 142
8.2.6.1.4 HIBICLENS 142
8.2.6.1.5 OTHERS 142
8.2.6.2 OCTENISEPT 142
8.2.6.3 POLYHEXANIDE SOLUTIONS 142
8.2.6.4 OTHERS 143
8.2.7 INTRAVENOUS IMMUNOGLOBULIN 143
8.2.8 CYCLOSPORINE 143
8.2.8.1 NEORAL 143
8.2.8.2 SANDIMMUNE 143
8.2.8.3 OTHERS 143
8.2.9 TUMOR NECROSIS FACTOR-ALPHA (TNF-)BLOCKING AGENT (ETANERCEPT) 143
8.2.10 OTHER TREATMENT 144
8.2.10.1 CYCLOPHOSPHAMIDE 144
8.2.10.2 N-ACETYLCYSTEINE 144
8.2.10.3 MONOCLONAL ANTIBODIES 144
8.2.10.4 THALIDOMIDE 144
8.3 SUPPORT CARE 144
8.3.1 INTRAVENOUS (IV) FLUID AND ELECTROLYTES 145
8.3.2 PAIN MANAGEMENT 146
8.3.2.1 LIDOCAINE 146
8.3.2.2 OTHERS 146
8.3.3 NUTRITION SUPPORT 146
8.3.4 ORAL CARE 146
8.3.5 PLASMAPHERESIS 146
8.3.6 BANDAGES 146
8.3.6.1 BIOLOGICAL DRESSING 147
8.3.6.1.1 ALLOGRAFT 147
8.3.6.1.2 XENOGRAFT 147
8.3.6.1.3 HOMOGRAFT 147
8.3.6.1.4 OTHERS 147
8.3.6.2 BIOSYNTHETIC DRESSING 148
8.3.6.3 SILVER IMPREGNATED DRESSING 148
8.4 HOSPITALIZATION 148
8.5 ISOLATION 149
8.6 OINTMENTS 149
8.6.1 BENZOCAINE 150
8.6.2 AMERICAINE 150
8.6.3 ANBESOL 150
8.6.4 CHIGGEREX PLUS 150
8.6.5 OTHERS 151
8.7 OTHERS 151
9 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY DIAGNOSIS 152
9.1 OVERVIEW 153
9.2 PHYSICAL EXAM 156
9.3 SKIN BIOPSY 156
9.4 MEDICAL HISTORY 157
9.5 BLOOD TEST 158
9.5.1 COMPLETE BLOOD COUNT 159
9.5.2 ERYTHROCYTE SEDIMENTATION RATE 159
9.5.3 COAGULATION STUDIES 159
9.5.4 UREA AND ELECTROLYTES 160
9.5.5 LIVER FUNCTION TEST 160
9.6 CULTURES 160
9.7 OTHERS 161
10 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY CAUSE 162
10.1 OVERVIEW 163
10.2 SPECIFIC TREATMENT 166
10.3 INFECTION 166
10.4 OTHERS 167
11 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY ROUTE OF ADMINISTRATION 168
11.1 OVERVIEW 169
11.2 ORAL 172
11.3 PARENTERAL 172
11.3.1 INTRAVENOUS 173
11.3.2 SUBCUTANEOUS 173
11.3.3 OTHERS 173
11.4 TOPICAL 173
11.4.1 OINTMENTS 174
11.4.2 SOLUTION 174
11.4.3 CREAMS 175
11.4.4 OTHERS 175
11.5 OTHERS 175
12 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY DRUG TYPE 176
12.1 OVERVIEW 177
12.2 BRANDED 180
12.2.1 NEORAL 181
12.2.2 SANDIMMUNE 181
12.2.3 VISTARIL 181
12.2.4 DURAMORPH 181
12.2.5 FENTORA 181
12.2.6 ENBREL 181
12.2.7 OTHERS 181
12.3 GENERIC 181
13 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY THERAPY TYPE 183
13.1 OVERVIEW 184
13.2 COMBINATION THERAPY 187
13.3 MONOTHERAPY 187
14 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY PATIENT TYPE 189
14.1 OVERVIEW 190
14.2 GERIATRIC 193
14.2.1 FEMALE 194
14.2.2 MALE 194
14.3 ADULT 194
14.3.1 FEMALE 195
14.3.2 MALE 195
14.4 PEDIATRIC 195
15 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY END USER 197
15.1 OVERVIEW 198
15.2 HOSPITALS 201
15.3 SPECIALTY CLINICS 201
15.4 AMBULATORY SURGICAL CENTER 202
15.5 HOMECARE SETTING 203
15.6 OTHERS 203
16 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY DISTRIBUTION CHANNEL 205
16.1 OVERVIEW 206
16.2 RETAIL PHARMACIES 209
16.2.1 HOSPITAL ASSOCIATED PHARMACIES 210
16.2.2 DRUG STORE 210
16.2.3 ONLINE PHARMACIES 210
16.3 DIRECT TENDERS 210
16.4 OTHERS 211
17 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, BY REGION 212
17.1 MIDDLE EAST AND AFRICA 213
17.1.1 SOUTH AFRICA 229
17.1.2 SAUDI ARABIA 240
17.1.3 BAHRAIN 251
17.1.4 U.A.E 262
17.1.5 KUWAIT 273
17.1.6 OMAN 283
17.1.7 QATAR 294
17.1.8 EGYPT 305
17.1.9 ISRAEL 315
17.1.10 REST OF MIDDLE EAST AND AFRICA 326
18 MIDDLE EAST AND AFRICA SJS/TEN TREATMENT MARKET, COMPANY LANDSCAPE 327
18.1 COMPANY SHARE ANALYSIS: MIDDLE EAST AND AFRICA 327
19 SWOT ANALYSIS 328
20 COMPANY PROFILE 329
20.1 PFIZER INC. 329
20.1.1 COMPANY SNAPSHOT 329
20.1.2 REVENUE ANALYSIS 329
20.1.3 COMPANY SHARE ANALYSIS 330
20.1.4 PRODUCT PORTFOLIO 330
20.1.5 RECENT DEVELOPMENT 330
20.2 NOVARTIS AG 331
20.2.1 COMPANY SNAPSHOT 331
20.2.2 REVENUE ANALYSIS 331
20.2.3 COMPANY SHARE ANALYSIS 332
20.2.4 PRODUCT PORTFOLIO 332
20.2.5 RECENT DEVELOPMENT 332
20.3 MERCK & CO., INC. 333
20.3.1 COMPANY SNAPSHOT 333
20.3.2 REVENUE ANALYSIS 333
20.3.3 COMPANY SHARE ANALYSIS 334
20.3.4 PRODUCT PORTFOLIO 334
20.3.5 RECENT DEVELOPMENT 334
20.4 AMNEAL PHARMACEUTICAL LLC. 335
20.4.1 COMPANY SNAPSHOT 335
20.4.2 REVENUE ANALYSIS 335
20.4.3 COMPANY SHARE ANALYSIS 336
20.4.4 PRODUCT PORTFOLIO 336
20.4.5 RECENT DEVELOPMENT 336
20.5 AMGEN INC. 337
20.5.1 COMPANY SNAPSHOT 337
20.5.2 REVENUE ANALYSIS 337
20.5.3 PRODUCT PORTFOLIO 338
20.5.4 RECENT DEVELOPMENT 338
20.6 ADVACARE PHARMA 339
20.6.1 COMPANY SNAPSHOT 339
20.6.2 PRODUCT PORTFOLIO 339
20.6.3 RECENT DEVELOPMENT 339
20.7 BD 340
20.7.1 COMPANY SNAPSHOT 340
20.7.2 REVENUE ANALYSIS 340
20.7.3 PRODUCT PORTFOLIO 341
20.7.4 RECENT DEVELOPMENT 341
20.8 CARDINAL HEALTH 342
20.8.1 COMPANY SNAPSHOT 342
20.8.2 REVENUE ANALYSIS 342
20.8.3 PRODUCT PORTFOLIO 343
20.8.4 RECENT DEVELOPMENT 343
20.9 COLGATE-PALMOLIVE COMPANY 344
20.9.1 COMPANY SNAPSHOT 344
20.9.2 REVENUE ANALYSIS 344
20.9.3 PRODUCT PORTFOLIO 345
20.9.4 RECENT DEVELOPMENT 345

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